product

Etravirine 269055-15-4

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Basic Info

Common Name

etravirine

CAS Number

269055-15-4

Molecular Weight

435.277

Density

1.6±0.1 g/cm3

Boiling Point

637.4±65.0 °C at 760 mmHg

Molecular Formula

C20H15BrN6O

Melting Point

265ºC (dec.)

MSDS

N/A

Flash Point

339.3±34.3 °C

etravirine Biological Activity

Description

Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

Related Catalog

Signaling Pathways >> Anti-infection >> HIV

Signaling Pathways >> Anti-infection >> Reverse Transcriptase

Research Areas >> Infection

In Vitro

TMC125 is highly active against wild-type HIV-1 (50% effective concentration [EC50]=1.4 to 4.8 nM) and shows some activity against HIV-2 (EC50=3.5 μM). TMC125 also inhibits a series of HIV-1 group M subtypes and circulating recombinant forms and a group O virus. TMC125 has activity for 19 viruses with EC50 of < 5 nM[1].

In Vivo

Etravirine has a high genetic barrier to the development of resistance. In phase IIb trials in treatment-experienced patients, including those infected with virus resistant to NNRTIs and protease inhibitors (PIs), TMC125 is active against HIV resistant to currently available NNRTIs, with a similar tolerability profile to that of the control group[2].

References

[1]. Andries, K., et al. TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. Antimicrob Agents Chemother, 2004. 48(12): p. 468[2]. Lazzarin, A., et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, 2007. 370(9581): p. 39-48.

 

Company Introduction 

Wuhan Bosman Medicine Technology Co., Ltd. is a technological company with independent intellectual property rights, engaged in the development, production and operation of chemical products. Our company is a comprehensive enterprise integrating scientific and technological development and mass production. It is a factory specializing in the research and development and production of methylamine hydrochloride series products. The product quality is domestically leading. At the same time, we continue to explore and develop with the joint efforts of all employees of the company. The company has achieved rapid development, and its products are sold all over the world and are well received by customers. Our company has been responding to the call of the local government to speed up the adjustment of industrial structure and gradually expand production capacity. Currently, there are more than 600 employees in the factory and 29 technicians; among them, 11 are masters, 4 are PhDs, and 3 are MBAs. The annual planned production capacity of monomethylamine hydrochloride is more than 900 tons, the planned annual production capacity of dimethylamine hydrochloride is more than 500 tons, and the annual planned production capacity of trimethylamine hydrochloride is more than 700 tons. Products are exported to Southeast Asia, Europe, North America and South America. Our company's product quality is stable and reliable, and it has established friendly and stable business relationships with many well-known domestic and foreign companies. Our unit adheres to the principle of honest management, adheres to the tenet of quality assurance, and customer first, provides customers with products of outstanding quality and stable performance, and has won the unanimous recognition and favor of customers with efficient and perfect after-sales service. We look forward to working with colleagues and friends from all walks of life to create a new future.

 

Packaging  Details 

包装图-清晰.jpg

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Safe Shipment: 

 

We guarantee that your package will pass 100% through the US, UK, Australia, Netherlands, Canada, France, Germany, Spain, Belgium, Sweden, Poland, Russian, Ukraine, Kazakhstan, Czech Republic, Slovakia, Portugal.

We have freight forwarders in these countries / regions, and our customs clearance company will clear your parcels without any customs issues, sometimes even 1000 kg. Door to door service. Make sure you receive 100% of the goods. Let you have a good experience of our strong freight capacity.

 

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Basic Info

Common Name

etravirine

CAS Number

269055-15-4

Molecular Weight

435.277

Density

1.6±0.1 g/cm3

Boiling Point

637.4±65.0 °C at 760 mmHg

Molecular Formula

C20H15BrN6O

Melting Point

265ºC (dec.)

MSDS

N/A

Flash Point

339.3±34.3 °C

etravirine Biological Activity

Description

Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

Related Catalog

Signaling Pathways >> Anti-infection >> HIV

Signaling Pathways >> Anti-infection >> Reverse Transcriptase

Research Areas >> Infection

In Vitro

TMC125 is highly active against wild-type HIV-1 (50% effective concentration [EC50]=1.4 to 4.8 nM) and shows some activity against HIV-2 (EC50=3.5 μM). TMC125 also inhibits a series of HIV-1 group M subtypes and circulating recombinant forms and a group O virus. TMC125 has activity for 19 viruses with EC50 of < 5 nM[1].

In Vivo

Etravirine has a high genetic barrier to the development of resistance. In phase IIb trials in treatment-experienced patients, including those infected with virus resistant to NNRTIs and protease inhibitors (PIs), TMC125 is active against HIV resistant to currently available NNRTIs, with a similar tolerability profile to that of the control group[2].

References

[1]. Andries, K., et al. TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. Antimicrob Agents Chemother, 2004. 48(12): p. 468[2]. Lazzarin, A., et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, 2007. 370(9581): p. 39-48.

 

Company Introduction 

Wuhan Bosman Medicine Technology Co., Ltd. is a technological company with independent intellectual property rights, engaged in the development, production and operation of chemical products. Our company is a comprehensive enterprise integrating scientific and technological development and mass production. It is a factory specializing in the research and development and production of methylamine hydrochloride series products. The product quality is domestically leading. At the same time, we continue to explore and develop with the joint efforts of all employees of the company. The company has achieved rapid development, and its products are sold all over the world and are well received by customers. Our company has been responding to the call of the local government to speed up the adjustment of industrial structure and gradually expand production capacity. Currently, there are more than 600 employees in the factory and 29 technicians; among them, 11 are masters, 4 are PhDs, and 3 are MBAs. The annual planned production capacity of monomethylamine hydrochloride is more than 900 tons, the planned annual production capacity of dimethylamine hydrochloride is more than 500 tons, and the annual planned production capacity of trimethylamine hydrochloride is more than 700 tons. Products are exported to Southeast Asia, Europe, North America and South America. Our company's product quality is stable and reliable, and it has established friendly and stable business relationships with many well-known domestic and foreign companies. Our unit adheres to the principle of honest management, adheres to the tenet of quality assurance, and customer first, provides customers with products of outstanding quality and stable performance, and has won the unanimous recognition and favor of customers with efficient and perfect after-sales service. We look forward to working with colleagues and friends from all walks of life to create a new future.

 

Packaging  Details 

包装图-清晰.jpg

More items

 

 

Safe Shipment: 

 

We guarantee that your package will pass 100% through the US, UK, Australia, Netherlands, Canada, France, Germany, Spain, Belgium, Sweden, Poland, Russian, Ukraine, Kazakhstan, Czech Republic, Slovakia, Portugal.

We have freight forwarders in these countries / regions, and our customs clearance company will clear your parcels without any customs issues, sometimes even 1000 kg. Door to door service. Make sure you receive 100% of the goods. Let you have a good experience of our strong freight capacity.

 

Contact Us:

Any questions pls kindly contact us  

<p style=&quo

Basic Info

Common Name

etravirine

CAS Number

269055-15-4

Molecular Weight

435.277

Density

1.6±0.1 g/cm3

Boiling Point

637.4±65.0 °C at 760 mmHg

Molecular Formula

C20H15BrN6O

Melting Point

265ºC (dec.)

MSDS

N/A

Flash Point

339.3±34.3 °C

etravirine Biological Activity

Description

Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

Related Catalog

Signaling Pathways >> Anti-infection >> HIV

Signaling Pathways >> Anti-infection >> Reverse Transcriptase

Research Areas >> Infection

In Vitro

TMC125 is highly active against wild-type HIV-1 (50% effective concentration [EC50]=1.4 to 4.8 nM) and shows some activity against HIV-2 (EC50=3.5 μM). TMC125 also inhibits a series of HIV-1 group M subtypes and circulating recombinant forms and a group O virus. TMC125 has activity for 19 viruses with EC50 of < 5 nM[1].

In Vivo

Etravirine has a high genetic barrier to the development of resistance. In phase IIb trials in treatment-experienced patients, including those infected with virus resistant to NNRTIs and protease inhibitors (PIs), TMC125 is active against HIV resistant to currently available NNRTIs, with a similar tolerability profile to that of the control group[2].

References

[1]. Andries, K., et al. TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. Antimicrob Agents Chemother, 2004. 48(12): p. 468[2]. Lazzarin, A., et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, 2007. 370(9581): p. 39-48.

 

Company Introduction 

Wuhan Bosman Medicine Technology Co., Ltd. is a technological company with independent intellectual property rights, engaged in the development, production and operation of chemical products. Our company is a comprehensive enterprise integrating scientific and technological development and mass production. It is a factory specializing in the research and development and production of methylamine hydrochloride series products. The product quality is domestically leading. At the same time, we continue to explore and develop with the joint efforts of all employees of the company. The company has achieved rapid development, and its products are sold all over the world and are well received by customers. Our company has been responding to the call of the local government to speed up the adjustment of industrial structure and gradually expand production capacity. Currently, there are more than 600 employees in the factory and 29 technicians; among them, 11 are masters, 4 are PhDs, and 3 are MBAs. The annual planned production capacity of monomethylamine hydrochloride is more than 900 tons, the planned annual production capacity of dimethylamine hydrochloride is more than 500 tons, and the annual planned production capacity of trimethylamine hydrochloride is more than 700 tons. Products are exported to Southeast Asia, Europe, North America and South America. Our company's product quality is stable and reliable, and it has established friendly and stable business relationships with many well-known domestic and foreign companies. Our unit adheres to the principle of honest management, adheres to the tenet of quality assurance, and customer first, provides customers with products of outstanding quality and stable performance, and has won the unanimous recognition and favor of customers with efficient and perfect after-sales service. We look forward to working with colleagues and friends from all walks of life to create a new future.

 

Packaging  Details 

包装图-清晰.jpg

More items

 

 

Safe Shipment: 

 

We guarantee that your package will pass 100% through the US, UK, Australia, Netherlands, Canada, France, Germany, Spain, Belgium, Sweden, Poland, Russian, Ukraine, Kazakhstan, Czech Republic, Slovakia, Portugal.

We have freight forwarders in these countries / regions, and our customs clearance company will clear your parcels without any customs issues, sometimes even 1000 kg. Door to door service. Make sure you receive 100% of the goods. Let you have a good experience of our strong freight capacity.

 

Contact Us:

Any questions pls kindly contact us  

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